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The main side effect associated with primobolan is testosterone suppression, which is likely to be mild to moderate. This testosterone suppression may persist for longer than 5 weeks and thus may lead to increased libido, and/or sexual desire. Side effect of primobolan therapy may include insomnia, sweating, headache, and fatigue. Sustained Action A single pill was associated with a moderate, if not significant, increase of sex drive and decrease of sexual desire, though other studies had not seen a significant change in behavior [3, 12-16], and it is important to note that there is a significant difference in the effect size in male and female volunteers in this study [3]. It is unknown as to how much effect the drug's mechanism may have on the sexual side effects seen in men because the research has not been done in this population. It is likely that the drug may be better effective in the treatment of erectile dysfunction (ED) androgenetic alopecia. Sustained-action antiandrogenic compounds have not been widely used for testosterone therapy in men because they are thought to have unpredictable effects on other body organs including the heart, kidneys, and lungs[3]. In men using stable-release primobolan, the drug's mechanism of action is known, but there is no specific treatment target in males. The effects of a single dose of long-acting high-dose estradiol may be more effective than once-daily primobolan, but that study has not been conducted in this population. One concern about prolonged dosing of an antiantibody drug is that this may predispose a person to certain diseases that will manifest once these antibodies have been suppressed.[33] Therefore, many individuals have developed autoimmune diseases including type 1 diabetes and lupus that may not respond to antiangiogenic therapies. A high-dose primobolan may also lead to higher risk of type 2 diabetes and heart disease[3, 8, 9, 27, 28]. The only known risk factor for Type 2 diabetes is a family history of developing Type 2 diabetes. Primobolan was only investigated in a randomized, controlled placebo-controlled trial. Primobolan was tested in males between the ages of 20 and 60 years, however most of the subjects were patients aged 50 to 60 years. In a randomized, double-blind trial involving 1100 patients at a university in Thailand, the median total testosterone levels showed an increase in only 4 out of 11 subjects studied[33]. In contrast, in a nonrandomized, double-blind trial Related Article:
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